GPCRIPDB: Pairwise Alignments

   2005, GPCRIPDB.


The pairwise alignment has been generated with the "genewise" program of the Wise2 package. The output shows the protein sequence on the first line, followed by a line indicating the similarity level of the match, followed by 4 lines representing the DNA sequence; The DNA sequence descending in triplets, each triplet being a codon. The translation of each codon is shown above it.
Between the two protein sequences a line indicating the similarity of the match is printed. "+" indicates a conservative mismatch while "- "indicates a dramatic one. Mismatches are indicated by "***" in the left column in addition to "!" at the relevant position(s).


genewise $Name: wise2-2-0 $ (unreleased release)
This program is freely distributed under a GPL. See source directory
Copyright (c) GRL limited: portions of the code are from separate copyright

Query protein:       GNAI_ASTPE
Comp Matrix:         blosum62.bla
Gap open:            12
Gap extension:       2
Start/End            default
Target Sequence      APGPASMR_2
Strand:              forward
Start/End (protein)  default
Gene Paras:          human.gf
Codon Table:         codon.table
Subs error:          1e-05
Indel error:         1e-05
Model splice?        model
Model codon bias?    flat
Model intron bias?   tied
Null model           syn
Algorithm            623

genewise output
Score 866.08 bits over entire alignment
Scores as bits over a synchronous coding model

Warning: The bits scores is not probablistically correct for single seqs
See WWW help for more info.

GNAI_ASTPE         1 GCATSAEDKAAAERSKAIDRNLRIDGEKAAREVKLLLLGAGESGKSTIV 
                     GCATSAEDKAAAERSKAIDRNLRIDGEKAAREVKLLLLGAGESGKSTIV 
                     GCATSAEDKAAAERSKAIDRNLRIDGEKAAREVKLLLLGAGESGKSTIV 
APGPASMR_2         4 gtgaagggaggggctagagaaccagggaggaggatcctggggtgaaaag 
                     ggccgcaaacccagcactagatgtagaaccgatattttgcgacgagctt 
                     tcagcaatatctggaaaacataattaagtagacagttgatagacgtatc 


GNAI_ASTPE        50 KQMKIIHEEGYSEEDCKQYKPVVYSNTIQSMIAIIRAMGSLKVDFGDGD 
                     KQMKIIHEEGYSEEDCKQYKPVVYSNTIQSMIAIIRAMGSLKVDFGDGD 
                     KQMKIIHEEGYSEEDCKQYKPVVYSNTIQSMIAIIRAMGSLKVDFGDGD 
APGPASMR_2       151 acaaaacgggttgggtactacggtaaaacaaagaacgagtcaggtgggg 
                     aatattaaagacaaagaaaacttagactagttcttgctgctatatgaga 
                     agggtctaacttgattggcgagtccccagtgatcaacggccaacttttc 


GNAI_ASTPE        99 RTDDARQLFALAGQAEEGELSPELAAVMKRLWADGGVQGCFSRSREYQL 
                     RTDDARQLFALAGQAEEGELSPELAAVMKRLWADGGVQGCFSRSREYQL 
                     RTDDARQLFALAGQAEEGELSPELAAVMKRLWADGGVQGCFSRSREYQL 
APGPASMR_2       298 aagggccttgcggcgggggcacgtgggaacttgggggcgttaatagtcc 
                     gcaacgattctcgacaagatgcatccttagtgcaggtaggtggcgaaat 
                     agtcagggtcgtcgtgataactagatcgggagttaccatcctatggtac 


GNAI_ASTPE       148 NDSASYYLNALDRLAAPGYIPTQQDVLRTRVKTTGIVETHFTFKDLHFK 
                     NDSASYYLNALDRLAAPGYIPTQQDVLRTRVKTTGIVETHFTFKDLHFK 
                     NDSASYYLNALDRLAAPGYIPTQQDVLRTRVKTTGIVETHFTFKDLHFK 
APGPASMR_2       445 agtgtttcagtgccggcgtacaccggccaagaaagaggactatagccta 
                     aacccaatactagtcccgatccaaattgcgtaccgttacatctaatata 
                     ttccatctctgcatacacccaagatacaaacgtttcgatcctcactccg 


GNAI_ASTPE       197 MFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHES 
                     MFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHES 
                     MFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHES 
APGPASMR_2       592 atggggcctgaaatacttgggagaattggcagtgcgcgggggaacacgt 
                     ttatggagcagaagtagtagtcctttgtctgcaatttcaaaatagtaac 
                     gttgaagtagggagttctaagaaccctgtgtcctgcatatgagccgtgt 


GNAI_ASTPE       246 MKLFDSICNNKWFTETSIILFLNKKDLFEEKITKSPLTICFPEYTGSNT 
                     MKLFDSICNNKWFTETSIILFLNKKDLFEEKITKSPLTICFPEYTGSNT 
                     MKLFDSICNNKWFTETSIILFLNKKDLFEEKITKSPLTICFPEYTGSNT 
APGPASMR_2       739 aactgtataaattagataactcaaagttggaaaatccaattcgtagtaa 
                     tattactgaaagtcacctttttaaaattaaatcacctctgtcaacgcac 
                     ggatccccctggccgccccgcccggtgtgggccgaaccctcggctccca 


GNAI_ASTPE       295 YEEAAAYIQMQFEDLNKRKDQKEIYTHFTCATDTNNIQFVFDAVTDVII 
                     YEEAAAYIQMQFEDLNKRKDQKEIYTHFTCATDTNNIQFVFDAVTDVII 
                     YEEAAAYIQMQFEDLNKRKDQKEIYTHFTCATDTNNIQFVFDAVTDVII 
APGPASMR_2       886 tgggggtacactggcaacagcagatactatgagaaaactgtgggaggaa 
                     aaacccatatataataagaaaaatacatcgccacaatatttactcattt 
                     cgaagcctgggtgtgcgtgtgggcttccatcacccccgtctttcttcct 


GNAI_ASTPE       344 KNNLKDCGLF                                        
                     KNNLKDCGLF                                        
                     KNNLKDCGLF                                        
APGPASMR_2      1033 aaacagtgct                                        
                     aaataaggtt                                        
                     gctcgtctat                                        


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F.Horn (gpcrdbcmbi.kun.nl), 24-May-2005