GPCRIPDB: Pairwise Alignments

   2005, GPCRIPDB.


The pairwise alignment has been generated with the "genewise" program of the Wise2 package. The output shows the protein sequence on the first line, followed by a line indicating the similarity level of the match, followed by 4 lines representing the DNA sequence; The DNA sequence descending in triplets, each triplet being a codon. The translation of each codon is shown above it.
Between the two protein sequences a line indicating the similarity of the match is printed. "+" indicates a conservative mismatch while "- "indicates a dramatic one. Mismatches are indicated by "***" in the left column in addition to "!" at the relevant position(s).


genewise $Name: wise2-2-0 $ (unreleased release)
This program is freely distributed under a GPL. See source directory
Copyright (c) GRL limited: portions of the code are from separate copyright

Query protein:       GNAI3_CAVPO
Comp Matrix:         blosum62.bla
Gap open:            12
Gap extension:       2
Start/End            default
Target Sequence      CCGI3PAS3_2
Strand:              forward
Start/End (protein)  default
Gene Paras:          human.gf
Codon Table:         codon.table
Subs error:          1e-05
Indel error:         1e-05
Model splice?        model
Model codon bias?    flat
Model intron bias?   tied
Null model           syn
Algorithm            623

genewise output
Score 867.51 bits over entire alignment
Scores as bits over a synchronous coding model

Warning: The bits scores is not probablistically correct for single seqs
See WWW help for more info.

GNAI3_CAVPO        1 GCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIV 
                     GCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIV 
                     GCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIV 
CCGI3PAS3_2        4 gtacagggaggggcaaaagcatcggggaggaggacctcggggtgaaaag 
                     ggctgcaaacctaggattagatgaagaaccaatattttgcgacgagctt 
                     cctgccacggggggtggccccgggcggagcaaggggacttaggtatctg 


GNAI3_CAVPO       50 KQMKIIHEDGYSEEECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEPA 
                     KQMKIIHEDGYSEEECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEPA 
                     KQMKIIHEDGYSEEECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEPA 
CCGI3PAS3_2      151 acaaaacgggttgggtactagggtaaaactaagaaagagccaagtggcg 
                     aatattaaagacaaagaaaatttagactacttcttgctggtatatgacc 
                     aggacttatctagaataataatctcttagcctacaacgaatgtttgatc 


GNAI3_CAVPO       99 RADDARQLFVLAGSAEEGLMTSELAGVIRRLWRDGGVQACFSRSREYQL 
                     RADDARQLFVLAGSAEEGLMTSELAGVIRRLWRDGGVQACFSRSREYQL 
                     RADDARQLFVLAGSAEEGLMTSELAGVIRRLWRDGGVQACFSRSREYQL 
CCGI3PAS3_2      298 aggggccttgtggaggggcaatgtgggaacttcggggcgttaatagtcc 
                     gcaacgattttcggcaagttccatcgttggtggaggtacgtggcgaaat 
                     aatttggattagctgaaatgtaaaaattagagattgggacccacggtgc 


GNAI3_CAVPO      148 NDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFK 
                     NDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFK 
                     NDSASYYLNDLDRISQTNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFK 
CCGI3PAS3_2      445 agtgtttcagtgaatcaatacaccggccaagaaagaggactatagctta 
                     aacccaataatagtcacaatccaaattgcgtaccgttacatctaatata 
                     ttttatcattgtaaaaccctatgatttgaaggcactgaattccacaccg 


GNAI3_CAVPO      197 MFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHES 
                     MFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHES 
                     MFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHES 
CCGI3PAS3_2      592 atggggcatgcaatacttgggagaattggcagtgcgtgggggaacacga 
                     ttatggagcagaagtagtagtcctttgtctgaaatttcaaaatagtaag 
                     gttatcaaaaaaagtcttgagactcctgcctttcttatgtgggtagtac 


GNAI3_CAVPO      246 MKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNT 
                     MKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNT 
                     MKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNT 
CCGI3PAS3_2      739 aactgaataaattagataactcaaagctggaaaaactaattcgtagtaa 
                     tattagtgaaagtcacctttttaaaattaaataggctctgacaacgcac 
                     gactccttccagtactactcttcgacttaaaaagtaatcttcatattca 


GNAI3_CAVPO      295 YEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVII 
                     YEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVII 
                     YEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVII 
CCGI3PAS3_2      886 tgggggtactctggcaaaagaagatactatgagaaagctgtgggaggaa 
                     aaacccatagataataggaacaatacatcgccacaatatttactcattt 
                     tagattctgcgtatgcagatcggcttcccttaccgtggttttttatcct 


GNAI3_CAVPO      344 KNNLKECGLY                                        
                     KNNLKECGLY                                        
                     KNNLKECGLY                                        
CCGI3PAS3_2     1033 aaatagtgct                                        
                     aaataaggta                                        
                     actagatatt                                        


//


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F.Horn (gpcrdbcmbi.kun.nl), 24-May-2005