GPCRIPDB: Pairwise Alignments

   2005, GPCRIPDB.


The pairwise alignment has been generated with the "genewise" program of the Wise2 package. The output shows the protein sequence on the first line, followed by a line indicating the similarity level of the match, followed by 4 lines representing the DNA sequence; The DNA sequence descending in triplets, each triplet being a codon. The translation of each codon is shown above it.
Between the two protein sequences a line indicating the similarity of the match is printed. "+" indicates a conservative mismatch while "- "indicates a dramatic one. Mismatches are indicated by "***" in the left column in addition to "!" at the relevant position(s).


genewise $Name: wise2-2-0 $ (unreleased release)
This program is freely distributed under a GPL. See source directory
Copyright (c) GRL limited: portions of the code are from separate copyright

Query protein:       GNAI2_ORYLA
Comp Matrix:         blosum62.bla
Gap open:            12
Gap extension:       2
Start/End            default
Target Sequence      OLAB1742_2
Strand:              forward
Start/End (protein)  default
Gene Paras:          human.gf
Codon Table:         codon.table
Subs error:          1e-05
Indel error:         1e-05
Model splice?        model
Model codon bias?    flat
Model intron bias?   tied
Null model           syn
Algorithm            623

genewise output
Score 874.35 bits over entire alignment
Scores as bits over a synchronous coding model

Warning: The bits scores is not probablistically correct for single seqs
See WWW help for more info.

GNAI2_ORYLA        1 GCTVSQEDKAAADRSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIV 
                     GCTVSQEDKAAADRSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIV 
                     GCTVSQEDKAAADRSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIV 
OLAB1742_2         4 gtagacggaggggataaagaaccggggaggaggaccccggggtgaaaag 
                     ggctgaaaacccagcattaaatgaagaaccgatattttgcgacgagctt 
                     cttgcgacacgccgtagccacgaatagggggagagcggtcgggggcctg 


GNAI2_ORYLA       50 KQMKIIHEDGYSEDECKQYRAVVYSNTVQSIMAIIKAMTILHLDYERPE 
                     KQMKIIHEDGYSEDECKQYRAVVYSNTVQSIMAIIKAMTILHLDYERPE 
                     KQMKIIHEDGYSEDECKQYRAVVYSNTVQSIMAIIKAMTILHLDYERPE 
OLAB1742_2       151 acaaaacgggttgggtactagggtaaagctaagaaagaaacccgtgccg 
                     aatattaaagacaaagaaagcttagactacttcttactcttataaagca 
                     ggggtttatttaatgtgacaattcccccgccgtccacgccgtcctactg 


GNAI2_ORYLA       99 REEDAKRLFKMAAEAEERGDLPEELANIIKDLWADSGIQHCLTRAREYQ 
                     REEDAKRLFKMAAEAEERGDLPEELANIIKDLWADSGIQHCLTRAREYQ 
                     REEDAKRLFKMAAEAEERGDLPEELANIIKDLWADSGIQHCLTRAREYQ 
OLAB1742_2       298 aggggacctaaggggggcggccggtgaaaagctggtgacctcacgcgtc 
                     gaaacagttatccacaaggatcaatcattaatgcacgtaagtcgcgaaa 
                     agatcagctggtaaagggccctaggtctcgcggcttccgtccaatggta 


GNAI2_ORYLA      148 LNDSAAYYLKDLERISKPDYIPTQQDVLRTRVKTTGIVETHFTFKDLHF 
                     LNDSAAYYLKDLERISKPDYIPTQQDVLRTRVKTTGIVETHFTFKDLHF 
                     LNDSAAYYLKDLERISKPDYIPTQQDVLRTRVKTTGIVETHFTFKDLHF 
OLAB1742_2       445 cagtggttcagcgaaaacgtacaccggcaacgaaagaggactatagcct 
                     taacccaataatagtgacaatccaaattgcgtaccgttacatctaatat 
                     ccctccccgatgggacgaccccaggcggattggccccgagccccgcgtc 


GNAI2_ORYLA      197 KMFDVGGQRSERKKWIHCFEGVTAIIFCVAMSAYDLVLAEDEEMNRMHE 
                     KMFDVGGQRSERKKWIHCFEGVTAIIFCVAMSAYDLVLAEDEEMNRMHE 
                     KMFDVGGQRSERKKWIHCFEGVTAIIFCVAMSAYDLVLAEDEEMNRMHE 
OLAB1742_2       592 aatggggcctgaaatacttgggagaattggaagtgcgcgggggaacacg 
                     attatggagcagaagtagtagtcctttgtctgcaatttcaaaatagtaa 
                     ggttggcggagggggccccgactcctccgcgtgccgtgtgcgggcggcg 


GNAI2_ORYLA      246 SMKLFDSICNNKWFTETSIILFLNKKDLFEQKIAHSPLTICFPEYEGPN 
                     SMKLFDSICNNKWFTETSIILFLNKKDLFEQKIAHSPLTICFPEYEGPN 
                     SMKLFDSICNNKWFTETSIILFLNKKDLFEQKIAHSPLTICFPEYEGPN 
OLAB1742_2       739 aaactgtataaattagataactcaaagctgcaagcaccaattcgtggca 
                     gtattactgaaagtcacctttttaaaattaaatcagctctgtcaaagca 
                     cgggtccccccggcagccccccccggtgtgggtccctgcccccgcaacc 


GNAI2_ORYLA      295 TYQEAQAYIQTKFEDLNKKKETKEIYTHFTCATDTKNVQFVFDAVTDVI 
                     TYQEAQAYIQTKFEDLNKKKETKEIYTHFTCATDTKNVQFVFDAVTDVI 
                     TYQEAQAYIQTKFEDLNKKKETKEIYTHFTCATDTKNVQFVFDAVTDVI 
OLAB1742_2       886 atcggcgtacaatggcaaaagaagatactatgagaaagctgtgggagga 
                     caaacacatacataataaaaacaatacatcgccacaatatttactcatt 
                     gcggcggccgcgtgtacgggacgaccctcccctccgcggtcttccctcc 


GNAI2_ORYLA      344 IKNNLKDCGLF                                       
                     IKNNLKDCGLF                                       
                     IKNNLKDCGLF                                       
OLAB1742_2      1033 aaaacagtgct                                       
                     taaataaggtt                                       
                     cgccggccccc                                       


//


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F.Horn (gpcrdbcmbi.kun.nl), 24-May-2005