GPCRDB: Swiss-Prot entry

ID   Q6NXS0_HUMAN PRELIMINARY;      PRT;   379 AA.
AC   Q6NXS0;
DT   05-JUL-2004 (TrEMBLrel. 27, Created)
DT   05-JUL-2004 (TrEMBLrel. 27, Last sequence update)
DT   05-JUL-2004 (TrEMBLrel. 27, Last annotation update)
DE   Guanine nucleotide binding protein, alpha stimulating activity
DE   polypeptide 1, isoform b.
GN   Name=GNAS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; 
OC   Homo. 
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RX   MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RG   Mammalian Gene Collection Program Team;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RA   Director MGC Project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC       involved as modulators or transducers in various transmembrane
CC       signaling systems. The G(s) protein is involved in hormonal
CC       regulation of adenylate cyclase: it activates the cyclase in
CC       response to beta-adrenergic stimuli (By similarity).
CC   -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
CC       gamma. The alpha chain contains the guanine nucleotide binding
CC       site (By similarity).
DR   EMBL; BC066923; AAH66923.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P04896; 1AZS. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; Q6NXS0; 35-376.
DR   GO; GO:0005525; F:GTP binding; IEA.
DR   GO; GO:0004871; F:signal transducer activity; IEA.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA.
DR   GO; GO:0007165; P:signal transduction; IEA.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; IPR001019; Gprotein_alpha.
DR   InterPro; IPR000367; Gprotein_alpha_S.
DR   InterPro; IPR002885; PPR.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00503; G-alpha; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00443; GPROTEINAS.
DR   ProDom; PD000281; Gprotein_alpha; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00275; G_alpha; 1.
DR   TIGRFAMs; TIGR00756; PPR; 1.
DR   CMR; Q6NXS0.
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q6NXS0.
DR   PRESAGE; Q6NXS0.
DR   ModBase; Q6NXS0.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   GTP-binding; Transducer.
SQ   SEQUENCE   379 AA;  44239 MW;  6EC13163B79475B8 CRC64;
     MGYLGNSKTE DQRNEEKAQR EANKKIEKQL QKDKQVYRAT HRLLLLGAGE SGKSTIVKQM
     RILHVNGFNG DEKATKVQDI KNNLKEAIET IVAAMSNLVP PVELANPENQ FRVDYILSVM
     NVPDFDFPPE FYEHAKALWE DEGVRACYER SNEYQLIDCA QYFLDKIDVI KQADYVPSDQ
     DLLRCRVLTS GIFETKFQVD KVNFHMFDVG GQRDERRKWI QCFNDVTAII FVVASSSYNM
     VIREDNQTNR LQEALNLFKS IWNNRWLRTI SVILFLNKQD LLAEKVLAGK SKIEDYFPEF
     ARYTTPEDAT PEPGEDPRVT RAKYFIRDEF LRISTASGDG RHYCYPHFTC AVDTENIRRV
     FNDCRDIIQR MHLRQYELL
//