GPCRDB: Swiss-Prot entry

ID   Q5HZN4_XENLA PRELIMINARY;      PRT;   377 AA.
AC   Q5HZN4;
DT   10-MAY-2005 (TrEMBLrel. 30, Created)
DT   10-MAY-2005 (TrEMBLrel. 30, Last sequence update)
DT   10-MAY-2005 (TrEMBLrel. 30, Last annotation update)
DE   LOC496349 protein.
GN   Name=LOC496349;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; 
OC   Xenopodinae; Xenopus; Xenopus. 
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Egg;
RX   MEDLINE=22341132; PubMed=12454917 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Egg;
RX   MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RG   Mammalian Gene Collection Program Team;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Egg;
RA   Klein S., Gerhard D.S.;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC       involved as modulators or transducers in various transmembrane
CC       signaling systems (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane-bound (By similarity).
DR   EMBL; BC088948; AAH88948.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   GO; GO:0016020; C:membrane; IEA.
DR   GO; GO:0005525; F:GTP binding; IEA.
DR   GO; GO:0004871; F:signal transducer activity; IEA.
DR   GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA.
DR   GO; GO:0007165; P:signal transduction; IEA.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; IPR001019; Gprotein_alpha.
DR   InterPro; IPR000469; Gprotein_alpha12.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00503; G-alpha; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00440; GPROTEINA12.
DR   ProDom; PD000281; Gprotein_alpha; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00275; G_alpha; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   ProtoMap; Q5HZN4.
DR   PRESAGE; Q5HZN4.
DR   ModBase; Q5HZN4.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   GTP-binding; Membrane; Transducer.
SQ   SEQUENCE   377 AA;  43984 MW;  73A20297103DFE9D CRC64;
     MADFLPSHSM FSVCFPNCVL NSREADQQRK SKEIDRCLSR EKTYVKRLVK ILLLGAGESG
     KSTFLKQMRI IHGQDFDLRA KEEFRSTIYS NVIKGIRVLV DAREKLHIPW GESANQKHGE
     VMMAFDTRSA MVAQGMVETQ VFMAHLVSIR ALWADSGIQT AYDRRREFQL GESVKYFLDN
     LGKLGDKDYL PTQQDILLAR RPTKGIHEYD FEIKNVPFKM VDVGGQRSER KRWFECFDSV
     TSILFLVSSS EYDQVLMEDR QTNRLTESLN IFETIVNNRV FSNVSIILFL NKTDLLEEKV
     KIVSIKDYFA DFEGEPHCLE DVQKFLVNCF RNKRRDQQQK PLYHHFTTAI NTENIRLVFR
     DVKDTILHDN LKQLMLQ
//