GPCRDB: Swiss-Prot entry
ID GPA6_DICDI STANDARD; PRT; 153 AA.
AC P34044;
DT 01-FEB-1994 (Rel. 28, Created)
DT 01-FEB-1994 (Rel. 28, Last sequence update)
DT 01-FEB-2005 (Rel. 46, Last annotation update)
DE Guanine nucleotide-binding protein alpha-6 subunit (G alpha 6)
DE (Fragment).
GN Name=gpaF;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AX3;
RX MEDLINE=92028842; PubMed=1930158 [NCBI, ExPASy, EBI, Israel, Japan];
RA Wu L., Devreotes P.N.;
RT "Dictyostelium transiently expresses eight distinct G-protein alpha-
RT subunits during its developmental program.";
RL Biochem. Biophys. Res. Commun. 179:1141-1147(1991).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC involved as modulators or transducers in various transmembrane
CC signaling systems. Alpha-6 is involved in the folic acid
CC chemotaxis signal transduction pathway.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
CC gamma. The alpha chain contains the guanine nucleotide binding
CC site.
CC -!- DEVELOPMENTAL STAGE: Expressed primarily in vegetative cells.
CC -!- MISCELLANEOUS: There are 8 known alpha subunits in D.discoideum.
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR PIR; JH0247; JH0247.
DR HSSP; P10824; 1CIP. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR DictyBase; DDB0003758; gpaF.
DR InterPro; IPR001019; Gprotein_alpha.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00503; G-alpha; 1.
DR Pfam; Graphical view of domain structure.
DR ProDom; PD000281; Gprotein_alpha; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR BLOCKS; P34044.
DR ProtoNet; P34044.
DR ProtoMap; P34044.
DR PRESAGE; P34044.
DR DIP; P34044.
DR ModBase; P34044.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW GTP-binding; Multigene family; Transducer.
FT NP_BIND <1 2 GTP (By similarity).
FT NON_TER 1 1
FT NON_TER 153 153
SQ SEQUENCE 153 AA; 17728 MW; F4CCA520BC04BEDF CRC64;
KSTIFKQLKI LQENGLWTTK ELQEFSNTIY INIITQLQVL INAAESIGIQ LQPENIQLSK
DYLELNHSSV TWTKEIGENS VRLWNDSGIK STFEKRDKEF QLNDSAEYFF NNLQRVTQDN
YIPTPQDALR ARVTTKGIIE ADVTFDNINM KII
//