GPCRDB: Swiss-Prot entry
ID GNAI3_HUMAN STANDARD; PRT; 353 AA.
AC P08754; P17539;
DT 01-NOV-1988 (Rel. 09, Created)
DT 01-OCT-1994 (Rel. 30, Last sequence update)
DT 10-MAY-2005 (Rel. 47, Last annotation update)
DE Guanine nucleotide-binding protein G(k), alpha subunit (G(i) alpha-3).
GN Name=GNAI3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=88198230; PubMed=2834384 [NCBI, ExPASy, EBI, Israel, Japan];
RA Itoh H., Toyama R., Kozasa T., Tsukamoto T., Matsuoka M., Kaziro Y.;
RT "Presence of three distinct molecular species of Gi protein alpha
RT subunit. Structure of rat cDNAs and human genomic DNAs.";
RL J. Biol. Chem. 263:6656-6664(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=88068503; PubMed=3120178 [NCBI, ExPASy, EBI, Israel, Japan];
RA Beals C.R., Wilson C.B., Perlmutter R.M.;
RT "A small multigene family encodes Gi signal-transduction proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:7886-7890(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=88198244; PubMed=2452165 [NCBI, ExPASy, EBI, Israel, Japan];
RA Codina J., Olate J., Abramowitz J., Mattera R., Cook R.G.,
RA Birnbaumer L.;
RT "Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G
RT protein of receptor-regulated K+ channels.";
RL J. Biol. Chem. 263:6746-6750(1988).
RN [4]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=88247980; PubMed=3132707 [NCBI, ExPASy, EBI, Israel, Japan];
RA Kim S., Ang S.L., Bloch D.B., Bloch K.D., Kawahara Y., Tolman C.,
RA Lee R., Seidman J.G., Neer E.J.;
RT "Identification of cDNA encoding an additional alpha subunit of a
RT human GTP-binding protein: expression of three alpha i subtypes in
RT human tissues and cell lines.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:4153-4157(1988).
RN [5]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=87247315; PubMed=3109953 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1016/0014-5793(87)81228-0;
RA Didsbury J.R., Snyderman R.;
RT "Molecular cloning of a new human G protein. Evidence for two Gi
RT alpha-like protein families.";
RL FEBS Lett. 219:259-263(1987).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction
RT sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX MEDLINE=22388257; PubMed=12477932 [NCBI, ExPASy, EBI, Israel, Japan]; DOI=10.1073/pnas.242603899;
RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT "Generation and initial analysis of more than 15,000 full-length human
RT and mouse cDNA sequences.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN [9]
RP NUCLEOTIDE SEQUENCE OF 20-353.
RX PubMed=2440724 [NCBI, ExPASy, EBI, Israel, Japan];
RA Suki W.N., Abramowitz J., Mattera R., Codina J., Birnbaumer L.;
RT "The human genome encodes at least three non-allellic G proteins with
RT alpha i-type subunits.";
RL FEBS Lett. 220:187-192(1987).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC involved as modulators or transducers in various transmembrane
CC signaling systems. G(k) is the stimulatory G protein of receptor-
CC regulated K(+) channels.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
CC gamma. The alpha chain contains the guanine nucleotide binding
CC site.
CC -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC --------------------------------------------------------------------------
CC This Swiss-Prot entry is copyright. It is produced through a collaboration
CC between the Swiss Institute of Bioinformatics and the EMBL outstation -
CC the European Bioinformatics Institute. There are no restrictions on its
CC use as long as its content is in no way modified and this statement is not
CC removed.
CC --------------------------------------------------------------------------
DR EMBL; M20604; AAA35895.1; -; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M20597; AAA35895.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M20598; AAA35895.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M20599; AAA35895.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M20600; AAA35895.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M20601; AAA35895.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M20602; AAA35895.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M20603; AAA35895.1; JOINED; Genomic_DNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; J03005; AAA52557.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; J03198; AAA35896.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; J03238; AAA35939.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; M27543; AAA52579.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; AF493907; AAM12621.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; BT019974; AAV38777.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR EMBL; BC025285; AAH25285.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR PIR; S02348; RGHUI3.
DR HSSP; P10824; 1AS3. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR SMR; P08754; 4-347.
DR Ensembl; ENSG00000065135; Homo_sapiens
DR Genew; HGNC:4387; GNAI3.
DR CleanEx; HGNC:4387; GNAI3.
DR H-InvDB; HIX0000853; -.
DR MIM; 139370; -. [NCBI / EBI]
DR GeneCards; GNAI3.
DR GeneLynx; GNAI3.
DR GenAtlas; GNAI3.
DR SOURCE; GNAI3.
DR GO; GO:0003924; F:GTPase activity; TAS.
DR GO; GO:0007194; P:negative regulation of adenylate cyclase ac...; TAS.
DR GO; GO:0006810; P:transport; NAS.
DR InterPro; IPR001019; Gprotein_alpha.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; Graphical view of domain structure.
DR Pfam; PF00503; G-alpha; 1.
DR Pfam; Graphical view of domain structure.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00441; GPROTEINAI.
DR ProDom; PD000281; Gprotein_alpha; 1.
DR ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR CMR; P08754.
DR HOVERGEN [Family / Alignment / Tree]
DR BLOCKS; P08754.
DR ProtoNet; P08754.
DR ProtoMap; P08754.
DR PRESAGE; P08754.
DR DIP; P08754.
DR ModBase; P08754.
DR SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW ADP-ribosylation; GTP-binding; Lipoprotein; Multigene family;
KW Myristate; Transducer.
FT INIT_MET 0 0 By similarity.
FT NP_BIND 39 46 GTP (By similarity).
FT NP_BIND 199 203 GTP (By similarity).
FT NP_BIND 268 271 GTP (By similarity).
FT MOD_RES 177 177 ADP-ribosylarginine (by cholera toxin).
FT MOD_RES 350 350 ADP-ribosylcysteine (by pertussis toxin).
FT LIPID 1 1 N-myristoyl glycine (By similarity).
FT CONFLICT 20 20 R -> C (in Ref. 9).
SQ SEQUENCE 353 AA; 40401 MW; C1684127F9F39B8F CRC64;
GCTLSAEDKA AVERSKMIDR NLREDGEKAA KEVKLLLLGA GESGKSTIVK QMKIIHEDGY
SEDECKQYKV VVYSNTIQSI IAIIRAMGRL KIDFGEAARA DDARQLFVLA GSAEEGVMTP
ELAGVIKRLW RDGGVQACFS RSREYQLNDS ASYYLNDLDR ISQSNYIPTQ QDVLRTRVKT
TGIVETHFTF KDLYFKMFDV GGQRSERKKW IHCFEGVTAI IFCVALSDYD LVLAEDEEMN
RMHESMKLFD SICNNKWFTE TSIILFLNKK DLFEEKIKRS PLTICYPEYT GSNTYEEAAA
YIQCQFEDLN RRKDTKEIYT HFTCATDTKN VQFVFDAVTD VIIKNNLKEC GLY
//