GPCRDB: Swiss-Prot entry

ID   GNAI2_ORYLA    STANDARD;      PRT;   354 AA.
AC   O13055;
DT   28-FEB-2003 (Rel. 41, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate
DE   cyclase-inhibiting G alpha protein) (Gi2 alpha subunit) (Gi alpha c).
GN   Name=GNAI2;
OS   Oryzias latipes (Medaka fish) (Japanese ricefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; 
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Atherinomorpha; 
OC   Beloniformes; Adrianichthyidae; Oryziinae; Oryzias. 
OX   NCBI_TaxID=8090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Ovary;
RX   MEDLINE=98055713; PubMed=9395335 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Oba Y., Yoshikuni M., Tanaka M., Mita M., Nagahama Y.;
RT   "Inhibitory guanine-nucleotide-binding-regulatory protein alpha
RT   subunits in medaka (Oryzias latipes) oocytes -- cDNA cloning and
RT   decreased expression of proteins during oocyte maturation.";
RL   Eur. J. Biochem. 249:846-853(1997).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC       involved as modulators or transducers in various transmembrane
CC       signaling systems. The G(i) proteins are involved in hormonal
CC       regulation of adenylate cyclase: they inhibit the cyclase in
CC       response to beta-adrenergic stimuli.
CC   -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
CC       gamma. The alpha chain contains the guanine nucleotide binding
CC       site.
CC   -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AB001742; BAA20073.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   HSSP; P10824; 1GDD. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; O13055; 4-353.
DR   InterPro; IPR001019; Gprotein_alpha.
DR   InterPro; IPR001408; Gprotein_alpha_I.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00503; G-alpha; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00441; GPROTEINAI.
DR   ProDom; PD000281; Gprotein_alpha; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   SMART; SM00275; G_alpha; 1.
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; O13055.
DR   ProtoNet; O13055.
DR   ProtoMap; O13055.
DR   PRESAGE; O13055.
DR   DIP; O13055.
DR   ModBase; O13055.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   ADP-ribosylation; GTP-binding; Lipoprotein; Multigene family;
KW   Myristate; Palmitate; Transducer.
FT   INIT_MET      0      0       By similarity.
FT   NP_BIND      39     46       GTP (By similarity).
FT   NP_BIND     200    204       GTP (By similarity).
FT   NP_BIND     269    272       GTP (By similarity).
FT   MOD_RES     178    178       ADP-ribosylarginine (by cholera toxin)
FT                                (By similarity).
FT   MOD_RES     351    351       ADP-ribosylcysteine (by pertussis toxin)
FT                                (By similarity).
FT   LIPID         1      1       N-myristoyl glycine (By similarity).
FT   LIPID         2      2       S-palmitoyl cysteine (By similarity).
SQ   SEQUENCE   354 AA;  40862 MW;  C5D64B0970E3BDD3 CRC64;
     GCTVSQEDKA AADRSKMIDK NLREDGEKAA REVKLLLLGA GESGKSTIVK QMKIIHEDGY
     SEDECKQYRA VVYSNTVQSI MAIIKAMTIL HLDYERPERE EDAKRLFKMA AEAEERGDLP
     EELANIIKDL WADSGIQHCL TRAREYQLND SAAYYLKDLE RISKPDYIPT QQDVLRTRVK
     TTGIVETHFT FKDLHFKMFD VGGQRSERKK WIHCFEGVTA IIFCVAMSAY DLVLAEDEEM
     NRMHESMKLF DSICNNKWFT ETSIILFLNK KDLFEQKIAH SPLTICFPEY EGPNTYQEAQ
     AYIQTKFEDL NKKKETKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKD CGLF
//