GPCRDB: Swiss-Prot entry

ID   GNAI2_CANFA    STANDARD;      PRT;   354 AA.
AC   P38400;
DT   01-OCT-1994 (Rel. 30, Created)
DT   01-OCT-1994 (Rel. 30, Last sequence update)
DT   10-MAY-2005 (Rel. 47, Last annotation update)
DE   Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate
DE   cyclase-inhibiting G alpha protein).
GN   Name=GNAI2;
OS   Canis familiaris (Dog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; 
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Fissipedia; Canidae; 
OC   Canis. 
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=90003652; PubMed=2477170 [NCBI, ExPASy, EBI, Israel, Japan];
RA   Holmer S.R., Stevens S., Homcy C.J.;
RT   "Tissue- and species-specific expression of inhibitory guanine
RT   nucleotide-binding proteins. Cloning of a full-length complementary
RT   DNA from canine heart.";
RL   Circ. Res. 65:1136-1140(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Boudreaux M.K.;
RT   "Guanine nucleotide-binding regulatory protein, alpha inhibitory
RT   subunit mRNA.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are
CC       involved as modulators or transducers in various transmembrane
CC       signaling systems. The G(i) proteins are involved in hormonal
CC       regulation of adenylate cyclase: they inhibit the cyclase in
CC       response to beta-adrenergic stimuli.
CC   -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and
CC       gamma. The alpha chain contains the guanine nucleotide binding
CC       site. Interacts with UNC5B (By similarity).
CC   -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC   --------------------------------------------------------------------------
CC   This Swiss-Prot entry is copyright. It is produced through a collaboration
CC   between  the Swiss Institute of Bioinformatics  and the  EMBL outstation -
CC   the European Bioinformatics Institute.  There are no  restrictions on  its
CC   use as long as its content is in no way modified and this statement is not
CC   removed.
CC   --------------------------------------------------------------------------
DR   EMBL; AY563036; AAS67003.1; -; mRNA. [EMBL / GenBank / DDBJ] [CoDingSequence]
DR   PIR; A61031; A61031.
DR   HSSP; P10824; 1AS3. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
DR   SMR; P38400; 4-353.
DR   Ensembl; ENSCAFG00000010740; Canis_familiaris
DR   InterPro; IPR001019; Gprotein_alpha.
DR   InterPro; IPR001408; Gprotein_alpha_I.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; Graphical view of domain structure.
DR   Pfam; PF00503; G-alpha; 1.
DR   Pfam; Graphical view of domain structure.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00441; GPROTEINAI.
DR   ProDom; PD000281; Gprotein_alpha; 1.
DR   ProDom [Domain structure / List of seq. sharing at least 1 domain ]
DR   HOVERGEN [Family / Alignment / Tree]
DR   BLOCKS; P38400.
DR   ProtoNet; P38400.
DR   ProtoMap; P38400.
DR   PRESAGE; P38400.
DR   DIP; P38400.
DR   ModBase; P38400.
DR   SWISS-2DPAGE; GET REGION ON 2D PAGE.
KW   ADP-ribosylation; GTP-binding; Lipoprotein; Multigene family;
KW   Myristate; Palmitate; Transducer.
FT   INIT_MET      0      0       By similarity.
FT   NP_BIND      39     46       GTP (By similarity).
FT   NP_BIND     200    204       GTP (By similarity).
FT   NP_BIND     269    272       GTP (By similarity).
FT   MOD_RES     178    178       ADP-ribosylarginine (by cholera toxin).
FT   MOD_RES     351    351       ADP-ribosylcysteine (by pertussis toxin).
FT   LIPID         1      1       N-myristoyl glycine (By similarity).
FT   LIPID         2      2       S-palmitoyl cysteine (By similarity).
SQ   SEQUENCE   354 AA;  40415 MW;  93A01B69AA9DBDE7 CRC64;
     GCTVSAEDKA AAERSKMIDK NLREDGEKAA REVKLLLLGA GESGKSTIVK QMKIIHEDGY
     SEEECRQYRA VVYSNTIQSI MAIVKAMGNL QIDFDDPSRA DDARQLFALS CTAEEQGVLP
     EDLSCVIRRL WADNGVQACF GRSREYQLND SAAYYLNDLE RIAQSDYIPT QQDVLRTRVK
     TTGIVETHFT FKDLHFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSAY DLVLAEDEEM
     NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKITH SPLTICFPEY TGANKYEEAA
     SYIQSKFEDL NKRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKD CGLF
//