GPCRDB: phylogenetic trees

This list allows you to jump to the phylogenetic trees of the receptor families, subfamilies, groups, etc. The family names are hyperlinked to the family pages and the numbers (20,40,60,80) are hyperlinked to the trees.

Information is available for the following families:

Jump to the GPCR families:
Putative families:
Orphans:
- Putative / unclassified GPCRs
and for the following non-GPCR families:
- Class Z Archaeal/bacterial/fungal opsins

Class A Rhodopsin like: for up to 20 , 40 , 60 , 80 sequences
- Amine: for up to 20 , 40 , 60 , 80 sequences
  - Muscarinic acetylcholine: for up to 20 , 40 , 60 sequences
    - Musc. acetylcholine Vertebrate type 1: for up to 20 sequences
    - Musc. acetylcholine Vertebrate type 2: for up to 20 sequences
    - Musc. acetylcholine Vertebrate type 3: for up to 20 sequences
    - Musc. acetylcholine Vertebrate type 4: for up to 20 sequences
    - Musc. acetylcholine Vertebrate type 5: for up to 20 sequences
    - Musc. acetylcholine Non Vertebrate: for up to 20 sequences
  - Adrenoceptors: for up to 20 , 40 , 60 , 80 sequences
    - Alpha Adrenoceptors: for up to 20 , 40 , 60 sequences
      - Alpha Adrenoceptors type 1: for up to 20 sequences
      - Alpha Adrenoceptors type 2: for up to 20 , 40 sequences
    - Beta Adrenoceptors: for up to 20 , 40 sequences
      - Beta Adrenoceptors type 1: for up to 20 sequences
      - Beta Adrenoceptors type 2: for up to 20 sequences
      - Beta Adrenoceptors type 3: for up to 20 sequences
  - Dopamine: for up to 20 , 40 , 60 , 80 sequences
    - Dopamine Vertebrate type 1: for up to 20 sequences
    - Dopamine Vertebrate type 2: for up to 20 sequences
    - Dopamine Vertebrate type 3: for up to 20 sequences
    - Dopamine Vertebrate type 4: for up to 20 sequences
    - Dopamine Insect: for up to 20 sequences
    - Dopamine Other: for up to 20 sequences
  - Histamine: for up to 20 , 40 sequences
    - Histamine type 1: for up to 20 sequences
    - Histamine type 2: for up to 20 sequences
    - Histamine type 3: for up to 20 sequences
    - Histamine type 4: for up to 20 sequences
  - Serotonin: for up to 20 , 40 , 60 , 80 sequences
    - Serotonin type 1: for up to 20 , 40 sequences
    - Serotonin type 2: for up to 20 sequences
    - Serotonin type 4: for up to 20 sequences
    - Serotonin type 5: for up to 20 sequences
    - Serotonin type 6: for up to 20 sequences
    - Serotonin type 7: for up to 20 sequences
    - Serotonin Other: for up to 20 sequences
  - Octopamine: for up to 20 sequences
  - Trace amine: for up to 20 , 40 , 60 sequences
- Peptide: tree not available
  - Angiotensin: for up to 20 sequences
    - Angiotensin type 1: for up to 20 sequences
    - Angiotensin type 2: for up to 20 sequences
  - Bombesin: for up to 20 sequences
  - Bradykinin: for up to 20 sequences
  - C5a anaphylatoxin: for up to 20 sequences
  - Fmet-leu-phe: for up to 20 sequences
  - APJ like: for up to 20 sequences
  - Interleukin-8: for up to 20 , 40 sequences
    - Interleukin-8 type A: for up to 20 sequences
    - Interleukin-8 type B: for up to 20 sequences
    - Interleukin-8 other: for up to 20 sequences
  - Chemokine: for up to 20 , 40 , 60 , 80 sequences
    - C-C Chemokine: for up to 20 , 40 , 60 , 80 sequences
      - C-C Chemokine type 1: for up to 20 sequences
      - C-C Chemokine type 2: for up to 20 sequences
      - C-C Chemokine type 3: for up to 20 sequences
      - C-C Chemokine type 4: for up to 20 sequences
      - C-C Chemokine type 5: for up to 20 , 40 , 60 , 80 sequences
      - C-C Chemokine type 6: for up to 20 sequences
      - C-C Chemokine type 7: for up to 20 sequences
      - C-C Chemokine type 8: for up to 20 sequences
      - C-C Chemokine type 9: for up to 20 sequences
      - C-C Chemokine type 10: for up to 20 sequences
      - C-C Chemokine type 11: for up to 20 sequences
      - C-C Chemokine type X: for up to 20 sequences
      - C-C Chemokine other: for up to 20 sequences
    - C-X-C Chemokine: for up to 20 , 40 , 60 sequences
      - C-X-C Chemokine type 3: for up to 20 sequences
      - C-X-C Chemokine type 4: for up to 20 sequences
      - C-X-C Chemokine type 5: for up to 20 sequences
      - C-X-C Chemokine type 6 (Bonzo): for up to 20 sequences
    - C-X3-C Chemokine: for up to 20 sequences
    - XC Chemokine: for up to 20 sequences
  - Cholecystokinin CCK: for up to 20 sequences
    - CCK type A: for up to 20 sequences
    - CCK type B: for up to 20 sequences
    - CCK other: tree not available
  - Endothelin: for up to 20 sequences
  - Melanocortin: for up to 20 , 40 , 60 , 80 sequences
    - Melanocyte stimulating hormone: for up to 20 , 40 , 60 , 80 sequences
    - Adrenocorticotropic hormone: for up to 20 sequences
    - Melanocortin hormone: for up to 20 , 40 sequences
  - Duffy antigen: for up to 20 sequences
  - Prolactin-releasing peptide (GPR10): for up to 20 sequences
  - Neuropeptide Y: for up to 20 , 40 , 60 sequences
    - Neuropeptide Y type 1: for up to 20 sequences
    - Neuropeptide Y type 2: for up to 20 sequences
    - Neuropeptide Y type 4: for up to 20 sequences
    - Neuropeptide Y type 5: for up to 20 sequences
    - Neuropeptide Y type 6/7: tree not available
    - Neuropeptide Y / peptide YY: for up to 20 sequences
    - Neuropeptide Y other: for up to 20 sequences
  - Neurotensin: for up to 20 sequences
  - Opioid: for up to 20 , 40 , 60 , 80 sequences
    - Opioid type D: for up to 20 sequences
    - Opioid type K: for up to 20 sequences
    - Opioid type M: for up to 20 , 40 sequences
    - Opioid type X: for up to 20 sequences
  - Somatostatin: for up to 20 , 40 sequences
    - Somatostatin type 1: for up to 20 sequences
    - Somatostatin type 2: for up to 20 sequences
    - Somatostatin type 3: for up to 20 sequences
    - Somatostatin type 4: for up to 20 sequences
    - Somatostatin type 5: for up to 20 sequences
  - Tachykinin: for up to 20 , 40 sequences
    - Substance P (NK1): for up to 20 sequences
    - Substance K (NK2): for up to 20 sequences
    - Neuromedin K (NK3): for up to 20 sequences
    - Tachykinin like 1: tree not available
    - Tachykinin like 2: for up to 20 sequences
  - Vasopressin-like: for up to 20 sequences
    - Vasopressin / vasotocin: for up to 20 sequences
      - Vasopressin type 1: for up to 20 sequences
      - Vasopressin type 2: for up to 20 sequences
      - Vasotocin: for up to 20 sequences
    - Oxytocin / mesotocin: for up to 20 sequences
    - Conopressin: for up to 20 sequences
  - Galanin like: for up to 20 sequences
    - Galanin: for up to 20 sequences
    - Allatostatin: for up to 20 sequences
    - Kiss receptor (GPR54): for up to 20 sequences
  - Proteinase-activated like: for up to 20 sequences
    - Thrombin: for up to 20 sequences
    - Proteinase-activated: for up to 20 sequences
  - Orexin & neuropeptides FF,QRFP: for up to 20 sequences
    - Orexin: for up to 20 sequences
    - Neuropeptide FF: for up to 20 sequences
    - Orexigenic neuropeptide QRFP: for up to 20 sequences
  - Urotensin II: for up to 20 sequences
  - Adrenomedullin (G10D): for up to 20 sequences
  - GPR37 / endothelin B-like: for up to 20 sequences
  - Chemokine receptor-like: for up to 20 sequences
    - Chemokine receptor-like 1: for up to 20 sequences
    - Chemokine receptor-like 2: for up to 20 sequences
  - Neuromedin U like: for up to 20 sequences
    - Neuromedin U: for up to 20 sequences
    - PRXamide: for up to 20 sequences
  - Somatostatin- and angiogenin-like peptide: for up to 20 sequences
  - Allatostatin C / drostatin C: for up to 20 sequences
  - Melanin-concentrating hormone receptors: for up to 20 sequences
  - Prokineticin receptors: for up to 20 sequences
  - Sulfakinin / CCKLR: for up to 20 sequences
  - Other peptide receptors: for up to 20 sequences
- Hormone protein: for up to 20 , 40 , 60 sequences
  - Follicle stimulating hormone: for up to 20 sequences
  - Lutropin-choriogonadotropic hormone: for up to 20 sequences
  - Thyrotropin: for up to 20 sequences
  - Gonadotropin type I: for up to 20 sequences
  - Gonadotropin type II: for up to 20 sequences
- (Rhod)opsin: for up to 20 , 40 , 60 , 80 sequences
  - Rhodopsin Vertebrate: for up to 20 , 40 , 60 , 80 sequences
    - Rhodopsin Vertebrate type 1: for up to 20 , 40 , 60 , 80 sequences
    - Rhodopsin Vertebrate type 2: for up to 20 , 40 , 60 , 80 sequences
    - Rhodopsin Vertebrate type 3: for up to 20 , 40 , 60 sequences
    - Rhodopsin Vertebrate type 4: for up to 20 , 40 , 60 , 80 sequences
    - Rhodopsin Vertebrate type 5: for up to 20 , 40 , 60 , 80 sequences
  - Rhodopsin Arthropod: for up to 20 , 40 , 60 , 80 sequences
    - Rhodopsin Arthropod type 1: for up to 20 , 40 sequences
    - Rhodopsin Arthropod type 2: for up to 20 sequences
    - Rhodopsin Arthropod type 3: tree not available
  - Rhodopsin Mollusc: for up to 20 sequences
  - Rhodopsin Other: for up to 20 , 40 , 60 sequences
- Olfactory: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 1 / MOR125-138,156: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 2 / MOR256-262,270-285: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 3 / MOR255: for up to 20 sequences
  - Olfactory II fam 4 / MOR225-248: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 5 / MOR172-224,249,254: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 6 / MOR103-105,107-119: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 7 / MOR139-155: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 8 / MOR161-171: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 9 / MOR120: for up to 20 , 40 sequences
  - Olfactory II fam 10 / MOR263-269: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory II fam 11 / MOR106,121-122: for up to 20 sequences
  - Olfactory II fam 12 / MOR250: for up to 20 sequences
  - Olfactory II fam 13 / MOR253: for up to 20 , 40 , 60 sequences
  - Olfactory unclassified class II: for up to 20 sequences
  - Olfactory I fam 51-52 /MOR1-42: for up to 20 , 40 , 60 , 80 sequences
  - Olfactory FOR-like (fish): for up to 20 , 40 , 60 , 80 sequences
  - Olfactory XOR-like (frog): for up to 20 sequences
  - Other ORs (class III fish ORs): for up to 20 sequences
- Prostanoid: for up to 20 , 40 , 60 , 80 sequences
  - Prostaglandin: for up to 20 , 40 , 60 sequences
    - Prostaglandin E2 subtype EP1: for up to 20 sequences
    - Prostaglandin E2/D2 subtype EP2: for up to 20 sequences
    - Prostaglandin E2 subtype EP3: for up to 20 sequences
    - Prostaglandin E2 subtype EP4: for up to 20 sequences
    - Prostaglandin F2-alpha: for up to 20 sequences
  - Prostacyclin: for up to 20 sequences
  - Thromboxane: for up to 20 sequences
- Nucleotide-like: for up to 20 , 40 , 60 , 80 sequences
  - Adenosine: for up to 20 , 40 sequences
    - Adenosine type 1: for up to 20 sequences
    - Adenosine type 2: for up to 20 sequences
    - Adenosine type 3: for up to 20 sequences
  - Purinoceptors: for up to 20 , 40 , 60 , 80 sequences
    - Purinoceptor P2RY1-4,6,11 GPR91: for up to 20 sequences
    - Purinoceptor P2RY5,8,9,10 GPR35,92,174: for up to 20 sequences
    - Purinoceptor P2RY12-14 GPR87 (UDP-Glucose): for up to 20 sequences
- Cannabinoid: for up to 20 sequences
- Platelet activating factor: for up to 20 sequences
- Gonadotropin-releasing hormone: for up to 20 , 40 , 60 sequences
  - Gonadotropin-releasing hormone type I: for up to 20 sequences
  - Gonadotropin-releasing hormone type II: for up to 20 , 40 sequences
  - Adipokinetic hormone like: for up to 20 sequences
  - Corazonin: for up to 20 sequences
  - Gonadotropin-releasing hormone other: for up to 20 sequences
- Thyrotropin-releasing hormone & Secretagogue: for up to 20 sequences
  - Thyrotropin-releasing hormone: for up to 20 sequences
  - Growth hormone secretagogue: for up to 20 sequences
  - Growth hormone secretagogue like: for up to 20 sequences
  - Ecdysis-triggering hormone (ETHR): for up to 20 sequences
- Melatonin: for up to 20 sequences
- Viral: for up to 20 , 40 , 60 , 80 sequences
- Lysosphingolipid & LPA (EDG): for up to 20 , 40 sequences
  - Sphingosine 1-phosphate Edg-1: for up to 20 sequences
  - Lysophosphatidic acid Edg-2: for up to 20 sequences
  - Sphingosine 1-phosphate Edg-3: for up to 20 sequences
  - Lysophosphatidic acid Edg-4: for up to 20 sequences
  - Sphingosine 1-phosphate Edg-5: for up to 20 sequences
  - Sphingosine 1-phosphate Edg-6: for up to 20 sequences
  - Lysophosphatidic acid Edg-7: for up to 20 sequences
  - Sphingosine 1-phosphate Edg-8: for up to 20 sequences
  - Edg Other: for up to 20 sequences
- Leukotriene B4 receptor: for up to 20 sequences
  - Leukotriene B4 receptor BLT1: for up to 20 sequences
  - Leukotriene B4 receptor BLT2: for up to 20 sequences
- Class A Orphan/other: for up to 20 , 40 , 60 , 80 sequences
  - Putative neurotransmitters: for up to 20 sequences
  - SREB: for up to 20 sequences
  - Mas proto-oncogene & Mas-related (MRGs): for up to 20 , 40 , 60 sequences
  - RDC1: for up to 20 sequences
  - EBV-induced: for up to 20 sequences
  - ORPH: for up to 20 sequences
  - LGR like (hormone receptors): for up to 20 sequences
  - GPR: for up to 20 , 40 , 60 sequences
  - GPR45 like: for up to 20 sequences
  - Cysteinyl leukotriene: for up to 20 sequences
  - G-protein coupled bile acid receptor: for up to 20 sequences
  - Free fatty acid receptor (GP40,GP41,GP43): for up to 20 sequences
Class B Secretin like: for up to 20 , 40 , 60 , 80 sequences
- Calcitonin: for up to 20 sequences
- Corticotropin releasing factor: for up to 20 sequences
- Gastric inhibitory peptide: for up to 20 sequences
- Glucagon: for up to 20 sequences
- Growth hormone-releasing hormone: for up to 20 sequences
- Parathyroid hormone: for up to 20 sequences
- PACAP: for up to 20 sequences
- Secretin: for up to 20 sequences
- Vasoactive intestinal polypeptide: for up to 20 sequences
- Diuretic hormone: for up to 20 sequences
- EMR1: for up to 20 sequences
- Latrophilin: for up to 20 , 40 sequences
  - Latrophilin type 1: for up to 20 sequences
  - Latrophilin type 2: for up to 20 sequences
  - Latrophilin type 3: for up to 20 sequences
  - ETL receptors: for up to 20 sequences
- Brain-specific angiogenesis inhibitor (BAI): for up to 20 sequences
- Methuselah-like proteins (MTH): for up to 20 sequences
- Cadherin EGF LAG (CELSR): for up to 20 sequences
- Very large G-protein coupled receptor: for up to 20 sequences
Class C Metabotropic glutamate / pheromone: for up to 20 , 40 , 60 , 80 sequences
- Metabotropic glutamate: for up to 20 , 40 sequences
  - Metabotropic glutamate group I: for up to 20 sequences
  - Metabotropic glutamate group II: for up to 20 sequences
  - Metabotropic glutamate group III: for up to 20 sequences
  - Metabotropic glutamate other: for up to 20 sequences
- Calcium-sensing like: for up to 20 , 40 sequences
  - Extracellular calcium-sensing: for up to 20 sequences
  - Pheromone: for up to 20 sequences
  - calcium-sensing like other: for up to 20 sequences
- Putative pheromone receptors: for up to 20 sequences
- GABA-B: for up to 20 sequences
  - GABA-B subtype 1: for up to 20 sequences
  - GABA-B subtype 2: for up to 20 sequences
  - GABA-B like: for up to 20 sequences
  - GABA-B other: for up to 20 sequences
- Orphan GPRC5: for up to 20 sequences
- Orphan GPCR6: for up to 20 sequences
- Bride of sevenless proteins (BOSS): for up to 20 sequences
- Taste receptors (T1R): for up to 20 sequences
Class D Fungal pheromone: for up to 20 , 40 , 60 sequences
- Fungal pheromone A-Factor like (STE2,STE3): for up to 20 sequences
- Fungal pheromone B like (BAR,BBR,RCB,PRA): for up to 20 sequences
- Fungal pheromone M- and P-Factor: tree not available
Class E cAMP receptors: for up to 20 sequences
Ocular albinism proteins: for up to 20 sequences
Frizzled/Smoothened family: for up to 20 , 40 , 60 , 80 sequences
- frizzled: for up to 20 , 40 , 60 , 80 sequences
  - frizzled Group A (Fz 1&2&4&5&7-9): for up to 20 , 40 , 60 , 80 sequences
  - frizzled Group B (Fz 3 & 6): for up to 20 sequences
  - frizzled Group C (other): for up to 20 sequences
- Smoothened: for up to 20 sequences
Insect odorant receptors: tree not available
Plant Mlo receptors: for up to 20 , 40 sequences
Nematode chemoreceptors: tree not available
- Nematode chemoreceptors type 1: for up to 20 , 40 , 60 , 80 sequences
  - Nematode chemoreceptors type 1 str: for up to 20 , 40 , 60 , 80 sequences
  - Nematode chemoreceptors type 1 stl: for up to 20 , 40 sequences
  - Nematode chemoreceptors type 1 srd: for up to 20 , 40 , 60 sequences
  - Nematode chemoreceptors type 1 other: for up to 20 , 40 , 60 , 80 sequences
- Nematode chemoreceptors type 2: for up to 20 , 40 , 60 , 80 sequences
- Nematode chemoreceptors other: for up to 20 sequences
Vomeronasal receptors (V1R & V3R): for up to 20 , 40 , 60 , 80 sequences
- Vomeronasal receptors V1RA: for up to 20 sequences
- Vomeronasal receptors V1RB: for up to 20 sequences
- Vomeronasal receptors V1RC: for up to 20 , 40 sequences
- Vomeronasal receptors V1RD (V3R): for up to 20 sequences
- Vomeronasal receptors V1RE: for up to 20 sequences
- Vomeronasal receptors V1RF: for up to 20 sequences
- Vomeronasal receptors V1RG: for up to 20 sequences
- Vomeronasal receptors V1RH: for up to 20 sequences
- Vomeronasal receptors V1RI: for up to 20 sequences
- Vomeronasal receptors V1RJ & VIRK: for up to 20 sequences
- Vomeronasal receptors V1RL: for up to 20 sequences
- Vomeronasal receptors others: for up to 20 sequences
Taste receptors T2R: for up to 20 , 40 , 60 , 80 sequences
Putative / unclassified GPCRs: tree not available
- Putative / unclassified Class A GPCRs: tree not available
- Putative / unclassified Class B GPCRs: tree not available
- Putative / unclassified Class C GPCRs: for up to 20 sequences
- Putative / unclassified Class D GPCRs: for up to 20 sequences
- Putative / unclassified Class E GPCRs: for up to 20 sequences
- Putative / unclassified other: tree not available
Class Z Archaeal/bacterial/fungal opsins: for up to 20 , 40 , 60 , 80 sequences
- Archaeal Bacteriorhodopsins: for up to 20 , 40 sequences
  - Archaeal bacteriorhodopsin type 1: for up to 20 sequences
  - Archaeal bacteriorhodopsin type 2: for up to 20 sequences
  - Archaeal bacteriorhodopsin type 3: for up to 20 sequences
- Bacterial (Proteorhod)opsins: for up to 20 sequences
- Fungal opsins: for up to 20 sequences
- Archaeal/bacterial/fungal opsins like: for up to 20 sequences
Human GPCRs: tree not available
- Human GPCRs - no olfactory receptors: tree not available
- Human GPCRs - no orphans: tree not available
- Human GPCRs - no olfactory,orphan: tree not available
- Human GPCRs - no olfactory,orphan,rhodopsin: tree not available

F.Horn (gpcrdbcmbi.ru.nl), 31-May-2006