Ligand dissociation constants for GPCRs

The data has kindly been made available by P. Seeman:: Seeman P. (1993) Receptor Tables, vol.2: Drug dissociation constants for neuroreceptors and transporters. Toronto: SZ Research.

Important note:
In the text files, an attempt has been made to associate the corresponding Swiss-Prot entry to the ligand binding data. However, the content of the AC line could be wrong as it has been filled in automatically by analysing the comments in the table, regarding the organism and the receptor subtype used.

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K values are available for the following families:

The K values refer to Ki or Kd values and provide information on the affinity of the ligands for the respective receptors.

Class A Rhodopsin like
- Amine
  - Acetylcholine (muscarinic): table or text file
    - Acetylcholine Vertebrate
      - Vertebrate type 1: table or text file
      - Vertebrate type 2: table or text file
      - Vertebrate type 3: table or text file
      - Vertebrate type 4: table or text file
      - Vertebrate type 5: table or text file
  - Adrenoceptors
    - Adrenoceptors Alpha type 1: table or text file
    - Adrenoceptors Alpha type 2: table or text file
    - Adrenoceptors Beta: table or text file
  - Dopamine
    - Dopamine Vertebrate type 1: table or text file
    - Dopamine Vertebrate type 2: table or text file
    - Dopamine Vertebrate type 3: table or text file
    - Dopamine Vertebrate type 4: table or text file
  - Histamine: table or text file
  - Serotonin
    - Serotonin Vertebrate type 1: table or text file
    - Serotonin Vertebrate type 2: table or text file
- Peptide
  - Opioid
    - Opioid type Delta: table or text file
    - Opioid type Kappa: table or text file
    - Opioid type Mu: table or text file
- Nucleotide
  - Adenosine
    - Adenosine type 1: table or text file
    - Adenosine type 2: table or text file
- Cannabis: table or text file
- Melatonin: table or text file
Class B Secretin like
Class C Metabotropic glutamate like
- GABA
Class D Pheromone
Class E Dicti

F. Horn 13-Apr-98