ACM5_HUMAN

Id Accession code Description Family Species Entry
ACM5_HUMAN P08912 Muscarinic acetylcholine receptor M5 Musc. acetylcholine Vertebrate type 5 Homo sapiens UniProt entry

Sequence

Sequence

This panel shows the sequence of the current proteins. All residues are clickable, the link will take you to a page that lists all available information for that residue, such as mutations and oligomer interface elements.
Hovering your mouse over a residue will display some additional inforation such as GPCRDB and Ballesteros-Weinstein numbers.

M E G D S Y H N A T
10		 T V N G T P V N H Q
20		 P L E R H R L W E V
30		 I T I A A V T A V V
40		 S L I T I V G N V L
50		 V M I S F K V N S Q
60		 L K T V N N Y Y L L
70		 S L A C A D L I I G
80		 I F S M N L Y T T Y
90		 I L M G R W A L G S
100
L A C D L W L A L D
110		 Y V A S N A S V M N
120		 L L V I S F D R Y F
130		 S I T R P L T Y R A
140		 K R T P K R A G I M
150		 I G L A W L I S F I
160		 L W A P A I L C W Q
170		 Y L V G K R T V P L
180		 D E C Q I Q F L S E
190		 P T I T F G T A I A
200
A F Y I P V S V M T
210		 I L Y C R I Y R E T
220		 E K R T K D L A D L
230		 Q G S D S V T K A E
240		 K R K P A H R A L F
250		 R S C L R C P R P T
260		 L A Q R E R N Q A S
270		 W S S S R R S T S T
280		 T G K P S Q A T G P
290		 S A N W A K A E Q L
300
T T C S S Y P S S E
310		 D E D K P A T D P V
320		 L Q V V Y K S Q G K
330		 E S P G E E F S A E
340		 E T E E T F V K A E
350		 T E K S D Y D T P N
360		 Y L L S P A A A H R
370		 P K S Q K C V A Y K
380		 F R L V V K A D G N
390		 Q E T N N G C H K V
400
K I M P C P F P V A
410		 K E P S T K G L N P
420		 N P S H Q M T K R K
430		 R V V L V K E R K A
440		 A Q T L S A I L L A
450		 F I I T W T P Y N I
460		 M V L V S T F C D K
470		 C V P V T L W H L G
480		 Y W L C Y V N S T V
490		 N P I C Y A L C N R
500
T F R K T F K M L L
510		 L C R W K K K K V E
520		 E K L Y W Q G N S K
530		 L P
532

Sequence annotations

Sequence annotation

The annotations you see in this panel are retrieved in real-time from several different sources using the Distributed Annotation System (DAS) protocol. This way you always have access to the most up-to-date information.

Annotations of the protein sequence are shown graphically. When you hover your mouse above one of the features, a little box that contains extra information appears.
If you want to know more about what a certain feature type means you can click on the feature types. This takes you to a page with information about what these features describe

SEQUENCE POSITIONAL FEATURES

Structure Elements

Structure elements

A protein structure consists of a sequence of structural elements (helices, loops). These elements are listed in this table.

For each element the 'local' residue numbering mapping is shown, and if available, the family numbers as well.
With local the residue numbers of this sequence are meant, starting at one and counting up.
Family numbers represent another type of numbering, where the numbers are valid for all proteins and independent of the residue numbers of individual protein sequences.

Structure elements

Snake plot

Snake plots

Snake plots (or resdiue-based diagrams) offer an intuitive way for looking at the sequence of a protein. In the plots, each residue in the transmembrane region is represented by a 'ball'. Those residues for which mutation data is available are clickable; when you hover your mouse over them, the pointer changes into the familiar 'hand/finger' icon. Clicking these residues takes you to a page with more information about the mutations found at that position.

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Mutations

Mutations

Clicking on the '+' sign shows a table with all available mutations. You can browse through the multiple pages in the table by using the links in the top-right corner of the table.

Residue types

The 'Original' and 'Mutated' columns list the original and mutant amino acid types of the mutant.

Residue numbers

The 'Residue #' column lists the residue numbers of the mutants. The numbers are the 'local' residue numbers. The 'GPCRDB #' and 'B&W #' columns list two types of 'global' residue numbers. These residue numbers uniquely identify a residue position across multiple protein sequences. Using these 'global' numbers you can easily compare residues from different proteins. The 'GPCRDB #' column shows the residue numbers that are used in the GPCRDB. Another 'global' residue numbering scheme is the Ballesteros-Weinstein (B&W) scheme.

Downloads

You can download the mutation table by clicking the 'Download all mutations' link. You will get a .txt file containing the information present in the table in 'tab-delimited' format.

Details

Clicking the 'details' link in the last column of the table takes you to a page that lists all available annotations of that mutation. These annotations can come from different sources and contain different types of data.

MuteXt and tinyGRAP mutation data