Welcome to the GPCRDB

The GPCRDB is a molecular-class information system that collects, combines, validates and stores large amounts of heterogenous data on G protein-coupled receptors (GPCRs). The GPCRDB contains data on sequences, ligand binding constants and mutations. In addition, many different types of computationally derived data are stored such as multiple sequence alignments and homology models. The GPCRDB is designed to be a data storage medium, as well as a tool to aid biomedical scientists with answering questions by offering a single point of access to many types of data that are integrated and visualized in a user-friendly way. Although most parts of the GPCRDB are self-explanatory, if you have not used this resource before we advice you to take a look at the usage page.

We advice you to take a look at the:
- updates page to see what has changed and what is new
- usage page to make sure you will quickly find your way

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The GPCRDB is introducing tools to browse X-ray structures, compare binding sites, profile similar receptors and generate amino acid conservation statistics. Snake plots and helix box diagrams can be custom colored, e.g. by chemical properties or mutation data, and saved as figures. The new tools can be found at tools.gpcr.org.

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NEW! GPCR-specific PDF reader

We are proud to release the GPCR-specific PDF reader, built using the best parts of the GPCRDB and the Utopia Documents PDF reader. The reader allows you to enrich your scientific literature with information and knowledge from the GPCRDB. More details can be found here. Try it!

The informal collaboration of GPCR databases

These include GPCRDB at the CMBI, the Netherlands (formerly at the EMBL), tinyGRAP Mutant Database at the CMBI (formerly at Tromso, Norway), The GPCR Oligomerization Knowledge Base (GPCR-OKB) at the Weill Medical College of Cornell University, Swiss-Prot and the GPCR Natural Variants Database (NaVa).

Current version: 2013.09.26